Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …

The choice of a phenotype is critical for the study of a complex genetically regulated process,
such as aging. To date, most of the twin and family studies have focused on broad survival …

Background The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology
of cardiovascular disease, is among the most comprehensively characterized multi-…

Objective. —To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …

Background— Visceral adipose tissue (VAT) compartments may confer increased metabolic
risk. The incremental utility of measuring both visceral and subcutaneous abdominal …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic
pathways plays a key role in the generation of amyloid β peptide (Aβ) in Alzheimer disease. …

The relation of resting heart rate on biennial ECG examinations to mortality rates over 30
years of follow-up of the Framingham cohort was examined based on 1876 total deaths and …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …