The term ‘extracellular vesicles’ refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

BACKGROUND Extracellular vesicles (EVs) are membrane-bound vesicles, found in biofluids,
that carry and transfer regulatory molecules, such as microRNAs (miRNAs) and proteins, …

… LC–MS includes imaging mass cytometry (2D), imaging mass cytometry (3D), LC–MS, LC–MS
bottom up and LC… or liquid chromatography–mass spectrometry (LC–MS). The spatial …

Genome-wide transcriptome analyses are routinely used to monitor tissue-, disease- and
cell type–specific gene expression, but it has been technically challenging to generate …

Our understanding of Alzheimer’s disease pathogenesis is currently limited by difficulties in
obtaining live neurons from patients and the inability to model the sporadic form of the …

Genomic stability is critical for the clinical use of human embryonic and induced pluripotent
stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on …

Background Cell-free DNA (cfDNA) testing for fetal trisomy is highly effective among high-risk
women. However, there have been few direct, well-powered studies comparing cfDNA …

OBJECTIVE: We sought to evaluate performance of a noninvasive prenatal test for fetal
trisomy 21 (T21) and trisomy 18 (T18). STUDY DESIGN: A multicenter cohort study was …

Background The pervasive expression of circular RNA is a recently discovered feature of gene
expression in highly diverged eukaryotes, but the functions of most circular RNAs are still …

… Laurent serves as an author on behalf of the SEARCH Alliance. Collaborators in the SEARCH
Alliance are listed in the Supplementary Appendix, available with the full text of this letter …