Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1

…, MA Cortez, G Kluger, LLE Koskinen… - Proceedings of the …, 2017 - National Acad Sciences
The clinical and electroencephalographic features of a canine generalized myoclonic epilepsy
with photosensitivity and onset in young Rhodesian Ridgeback dogs (6 wk to 18 mo) are …

[HTML][HTML] Identification of a novel idiopathic epilepsy locus in Belgian Shepherd dogs

EH Seppälä, LLE Koskinen, CH Gulløv, P Jokinen… - PloS one, 2012 - journals.plos.org
Epilepsy is the most common neurological disorder in dogs, with an incidence ranging from
0.5% to up to 20% in particular breeds. Canine epilepsy can be etiologically defined as …

Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus

…, E Einarsdottir, LLE Koskinen… - Experimental …, 2010 - Wiley Online Library
Please cite this paper as: Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms
are associated with discoid and subacute cutaneous lupus erythematosus. Experimental …

[HTML][HTML] IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease

E Einarsdottir, LLE Koskinen, E Dukes, K Kainu… - BMC medical …, 2009 - Springer
Background Association of the interleukin-23 receptor (IL23R) with inflammatory bowel
disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, …

[HTML][HTML] A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

…, T Haritunians, L Halme, LLE Koskinen… - Nature …, 2016 - nature.com
Protein-truncating variants protective against human disease provide in vivo validation of
therapeutic targets. Here we used targeted sequencing to conduct a search for protein-…

[HTML][HTML] Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia

…, V Holmberg, P Onkamo, LLE Koskinen… - Frontiers in …, 2017 - frontiersin.org
Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition.
Dysregulation of the complement system has been implicated, but molecular mechanisms …

The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency

…, E Einarsdottir, A de Kauwe, LLE Koskinen… - Genes & …, 2009 - nature.com
IgA deficiency (IgAD) and common variable immunodeficiency (CVID) often co-occur in
families, associating with chronic inflammatory diseases such as celiac disease (CD). ICOS (…

[HTML][HTML] ADAM23 is a common risk gene for canine idiopathic epilepsy

LLE Koskinen, EH Seppälä, J Weissl, TS Jokinen… - BMC genetics, 2017 - Springer
Background Idiopathic or genetic adult-onset epilepsy is a common neurological disorder in
domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few …

[HTML][HTML] Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene

LLE Koskinen, EH Seppälä, JM Belanger, M Arumilli… - BMC genomics, 2015 - Springer
Background Idiopathic epilepsy is a common neurological disease in human and domestic
dogs but relatively few risk genes have been identified to date. The seizure characteristics, …

The Psoriasis Risk Allele HLA-C*06:02 Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis

K Haapasalo, LLE Koskinen, J Suvilehto… - Infection and …, 2018 - Am Soc Microbiol
Pharyngeal tonsillitis is one of the most common upper respiratory tract infections, and group
A streptococcus is the most important bacterial pathogen causing it. While most patients …