User profiles for Lalit Kumar Golani
 | Lalit K. GolaniNortheastern University Verified email at northeastern.edu Cited by 457 |
Animal models of fatigue in major depressive disorder
PV Stutz, LK Golani, JM Witkin - Physiology & behavior, 2019 - Elsevier
Fatigue is common in a host of neurological and psychiatric disorders including depression
and often continues unabated even after primary symptoms of disease are treated. Its high …
and often continues unabated even after primary symptoms of disease are treated. Its high …
[HTML][HTML] Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni
Parasitic flatworm infections (eg tapeworms and fluke worms) are treated by a limited number
of drugs. In most cases, control is reliant upon praziquantel (PZQ) monotherapy. However, …
of drugs. In most cases, control is reliant upon praziquantel (PZQ) monotherapy. However, …
The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs: The example of CERC-611 and KRM-II-81
The need for improved antiepileptics is clearly mandated despite the existence of multiple
existing medicines from different chemical and mechanistic classes. Standard of care agents …
existing medicines from different chemical and mechanistic classes. Standard of care agents …
Synthesis and preclinical evaluation of novel 6-substituted pyrrolo [2, 3-d] pyrimidines as targeted antifolates
LK Golani, A Gangjee, C Cherian, S Orr… - Cancer Research, 2014 - AACR
Reduced folates are essential cofactors for biosynthesis of purines and pyrimidines. Since
humans do not synthesize folate, it is necessary to obtain these cofactors from dietary sources…
humans do not synthesize folate, it is necessary to obtain these cofactors from dietary sources…
Non-sedating benzodiazepines cause contractile paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni
Parasitic flatworm infections (eg tapeworms and fluke worms) are treated by a limited number
of drugs. In most cases, control is reliant upon praziquantel (PZQ) monotherapy. However, …
of drugs. In most cases, control is reliant upon praziquantel (PZQ) monotherapy. However, …
Papaverine ameliorates prenatal alcohol‐induced experimental attention deficit hyperactivity disorder by regulating neuronal function, inflammation, and oxidative …
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with complex
aetiology and phenotypes. Phosphodiesterase10A (PDE10A) has been shown to provide …
aetiology and phenotypes. Phosphodiesterase10A (PDE10A) has been shown to provide …
GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A ) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
[CITATION][C] Synthesis of analogs of KRM-II-81, gamma aminobutyric acid type A (GABAA) receptor u03b12/u03b13 subtype-selective ligand, for epilepsy treatment …
KP Pandey, LK Golani, JM Witkin… - American Chemical …, 2022 - ACS Publications
Epilepsy affects 1-2% of the global population and around 33% of those patients suffer from
refractory epilepsy. It is also a generally occurring neurological condition and one of the …
refractory epilepsy. It is also a generally occurring neurological condition and one of the …
PDE3 inhibition by cilostazol ameliorated behavioral and biochemical deficits in prenatal alcohol induced experimental ADHD
Background: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental
disorder with complex aetiology and phenotypes. Maternal consumption of alcohol is known to …
disorder with complex aetiology and phenotypes. Maternal consumption of alcohol is known to …
Vinpocetine, a PDE1 modulator, regulates markers of cerebral health, inflammation, and oxidative stress in a rat model of prenatal alcohol-induced experimental …
Prenatal alcohol exposure (PAE) has been shown to induce symptomatology associated with
attention deficit hyperactivity disorder (ADHD) by altering neurodevelopmental trajectories. …
attention deficit hyperactivity disorder (ADHD) by altering neurodevelopmental trajectories. …