Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of
human death. We examine newly discovered facets of tuberculosis pathogenesis and …

The granuloma, which is a compact aggregate of immune cells, is the hallmark structure of
tuberculosis. It is historically regarded as a host-protective structure that 'walls off' the infecting …

Granulomas, organized aggregates of immune cells, form in response to persistent stimuli
and are hallmarks of tuberculosis. Tuberculous granulomas have long been considered host-…

▪ Abstract Pathogenic mycobacteria, including the causative agents of tuberculosis and leprosy,
are responsible for considerable morbidity and mortality worldwide. A hallmark of these …

Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of
Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of the …

Infection of vertebrate hosts with pathogenic Mycobacteria, the agents of tuberculosis,
produces granulomas, highly organized structures containing differentiated macrophages and …

Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that
fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to …

Granulomas, organized aggregates of immune cells, are a hallmark of tuberculosis and
have traditionally been thought to restrict mycobacterial growth. However, analysis of …

Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert
protection by directing formation of granulomas, organized aggregates of macrophages and …

Granulomas are organized host immune structures composed of tightly interposed macrophages
and other cells that form in response to a variety of persistent stimuli, both infectious …