Whole genome sequencing is increasingly used to diagnose medical conditions of genetic
origin. While both coding and non-coding DNA variants contribute to a wide range of diseases…

Identifying causative variants in cis-regulatory elements (CRE) in neurodevelopmental
disorders has proven challenging. We have used in vivo functional analyses to categorize …

Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To
characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically …

RNA-binding proteins (RBPs) are central actors of RNA post-transcriptional regulation.
Experiments to profile-binding sites of RBPs in vivo are limited to transcripts expressed in the …

We present RBPNet, a novel deep learning method, which predicts CLIP-seq crosslink
count distribution from RNA sequence at single-nucleotide resolution. By training on up to a …

RNA-binding proteins (RBPs) are critical host factors for viral infection, however, large scale
experimental investigation of the binding landscape of human RBPs to viral RNAs is costly …

Legionella pneumophila (Lp.) is a bacterial pathogen which is a common causative agent of
pneumonia. In humans, it infects alveolar macrophages and transfers hundreds of virulence …

COVID-19 is a heterogeneous disease caused by SARS-CoV-2. Aside from infections of the
lungs, the disease can spread throughout the body and damage many other tissues, …

Viruses hijack the host cell’s machinery for the purpose of viral replication and interfere with
the activity of master regulatory proteins – including RNA binding proteins (RBPs). These …

Undiagnosed neurodevelopmental disease is significantly associated with rare variants in
cis-regulatory elements (CRE) but demonstrating causality is challenging as target gene …