In the human genome, most genes undergo splicing, and patterns of codon usage are splicing
dependent: guanine and cytosine (GC) content is the highest within single-exon genes …

Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion
1 , 2 . Here we reveal that most mutagenic DNA lesions are not resolved into a mutated …

Background Promoters are sites of transcription initiation that harbour a high concentration
of phenotype-associated genetic variation. The evolutionary gain and loss of promoters …

DNA base damage is a major source of oncogenic mutations 1 . Such damage can produce
strand-phased mutation patterns and multiallelic variation through the process of lesion …

Mutation in the germline is the ultimate source of genetic variation, but little is known about
the influence of germline chromatin structure on mutational processes. Using ATAC-seq, we …

Although multiple studies have addressed the effects of codon usage on gene expression,
such studies were typically performed in unspliced model genes. In the human genome, most …

Genetic mutations provide the raw material for evolution, they are responsible for heritable
disease and drive the development of cancer. It has been previously shown that the binding …

… Todo esto forma en el mundo una naturaleza de orden moral que tiende a vivir hasta en
las mismas agonías de la más absoluta descomposición; de tal manera, que su total …

… ; creació de vocabularis especialitzats dels diversos sectors; publicació periòdica de la
revista La Teranyina en col· laboració amb els altres dos territoris de parla catalana; impartició …

… , sin ser clérigos ni eclesiásticos en manera alguna, han tenido y tienen el hábito largo sin
ninguna obligación de su estado y sin haberles obligado a poner la garnacha»; de tal mane…