[HTML][HTML] Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism …

…, D Wagner, SV Bergner, LR Connolly… - PLoS …, 2013 - journals.plos.org
The fungus Fusarium fujikuroi causes “bakanae” disease of rice due to its ability to produce
gibberellins (GAs), but it is also known for producing harmful mycotoxins. However, the …

[HTML][HTML] The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters

LR Connolly, KM Smith, M Freitag - PLoS genetics, 2013 - journals.plos.org
The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans
and animals, yet coordinated transcriptional regulation of gene clusters remains largely a …

[HTML][HTML] Epigenetic Control of Effector Gene Expression in the Plant Pathogenic Fungus Leptosphaeria maculans

…, J Grandaubert, MH Balesdent, LR Connolly… - PLoS …, 2014 - journals.plos.org
Plant pathogens secrete an arsenal of small secreted proteins (SSPs) acting as effectors
that modulate host immunity to facilitate infection. SSP-encoding genes are often located in …

[HTML][HTML] Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes

K Schotanus, JL Soyer, LR Connolly… - Epigenetics & …, 2015 - Springer
Background Supernumerary chromosomes have been found in many organisms. In fungi,
these “accessory” or “dispensable” chromosomes are present at different frequencies in …

[PDF][PDF] Genetic manipulation of the Fusarium fujikuroi fusarin gene cluster yields insight into the complex regulation and fusarin biosynthetic pathway

…, P Wiemann, L Studt, CMK Sieber, LR Connolly… - Chemistry & Biology, 2013 - cell.com
In this work, the biosynthesis and regulation of the polyketide synthase/nonribosomal peptide
synthetase (PKS/NRPS)-derived mutagenic mycotoxin fusarin C was studied in the fungus …

Centromeres of filamentous fungi

KM Smith, JM Galazka, PA Phatale, LR Connolly… - Chromosome …, 2012 - Springer
How centromeres are assembled and maintained remains one of the fundamental questions
in cell biology. Over the past 20 years, the idea of centromeres as precise genetic loci has …

[HTML][HTML] Destabilization of chromosome structure by histone H3 lysine 27 methylation

…, M Stralucke, P Happel, KM Smith, LR Connolly… - PLoS …, 2019 - journals.plos.org
Chromosome and genome stability are important for normal cell function as instability often
correlates with disease and dysfunction of DNA repair mechanisms. Many organisms …

A metabolomics-guided approach to discover Fusarium graminearum metabolites after removal of a repressive histone modification

DA Adpressa, LR Connolly, ZM Konkel… - Fungal Genetics and …, 2019 - Elsevier
Many secondary metabolites are produced by biosynthetic gene clusters (BGCs) that are
repressed during standard growth conditions, which complicates the discovery of novel …

The multi-speed genome of Fusarium oxysporum reveals association of histone modifications with sequence divergence and footprints of past horizontal …

L Fokkens, S Shahi, LR Connolly, R Stam, SM Schmidt… - BioRxiv, 2018 - biorxiv.org
Fusarium oxysporum is an economically important pathogen causing wilting or rotting
disease symptoms in a large number of crops. It is proposed to have a structured, “two-speed” …

Chromatin analyses of Zymoseptoria tritici: Methods for chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq)

JL Soyer, M Möller, K Schotanus, LR Connolly… - Fungal Genetics and …, 2015 - Elsevier
The presence or absence of specific transcription factors, chromatin remodeling machineries,
chromatin modification enzymes, post-translational histone modifications and histone …