Proteomics plays a vital role in biomedical research in the post-genomic era. With the
technological revolution and emerging computational and statistic models, proteomic methodology …

Emerging evidence has suggested that the capability of a tumor to grow and propagate is
dependent on a small subset of cells within a tumor, termed cancer stem cells. Although data …

Context.— Immunomarkers with diagnostic, therapeutic, or prognostic values have been
increasingly used to maximize the benefits of clinical management of patients with neoplastic …

High salt is positively associated with the risk of many diseases. However, little is known
about the mechanisms. Here we showed that high salt increased proinflammatory molecules, …

In several organ systems, the transitional zone between different types of epithelium is a
hotspot for pre-neoplastic metaplasia and malignancy 1 , 2 , 3 , but the cells of origin for these …

Paneth cells are the primary source of C-type lysozyme, a β-1,4-N-acetylmuramoylhydrolase
that enzymatically processes bacterial cell walls. Paneth cells are normally present in …

Paneth cells are residents of the intestinal epithelium. Abnormal appearance of Paneth cells
has been widely documented in non-intestinal tissues within the digestive tract and even …

Objectives: The study clarified whether the T-helper (Th)1/Th2 imbalance existed only in
coronary arterial inflammation or in both coronary arterial inflammation and myocardial …

Bone metastasis is a major health threat to breast cancer patients. Tumor-derived Jagged1
represents a central node in mediating tumor-stromal interactions that promote osteolytic …

Triple-negative breast cancer (TNBC) patients have the worst prognosis and distant
metastasis-free survival among all major subtypes of breast cancer. The poor clinical outlook is …