During development and aging, genome mutation leading to loss of heterozygosity (LOH)
can uncover recessive phenotypes within tissue compartments. This phenomenon occurs in …

Precise regulation of stem cell self-renewal and differentiation properties is essential for
tissue homeostasis. Using the adult Drosophila intestine to study molecular mechanisms …

The genome stability of adult stem cells is of particular importance as these cells maintain
long-term self-renewal capacity and can contribute extensively to adult tissues. During …

Pluripotent stem cells (PSCs) can self-renew indefinitely while maintaining the ability to
generate all cell types of the body. This plasticity is proposed to require heterogeneity in gene …

The genome stability of adult stem cells is of particular importance as these cells maintain
long-term self-renewal capacity and can contribute extensively to adult tissues. During …

… Chapter 1.1 is largely based on a review that I wrote in my third year (Al zouabi and Bardin
2020) with the goal in mind of using it for my thesis introduction: Al zouabi L and Bardin AJ (…

Cannabis preparations are gaining popularity among patients with various skin diseases. Due
to the lack of scientific evidence, dermatologists remain cautious about their prescriptions. …

The emerging literature on the so-called ‘Arab Spring’has largely focused on the evolution
of the uprisings in cities and power centres. In order to reach a more diversified and inner …

… I would like to thank my two best partners in crime in the lab, Lara and Marine, you are both
… I am so happy I got to share the PhD experience from the beginning with Lara, you taught me …

Tissue homeostasis relies on rewiring of stem cell transcriptional programs into those of
differentiated cells. Here, we investigate changes in chromatin occurring in a bipotent adult stem …