User profiles for Lara K. Mahal

Lara K. Mahal

Canada Excellence Research Chair in Glycomics, University of Alberta
Verified email at ualberta.ca
Cited by 9318

Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis

LK Mahal, KJ Yarema, CR Bertozzi - Science, 1997 - science.org
Cell surface oligosaccharides can be engineered to display unusual functional groups for
the selective chemical remodeling of cell surfaces. An unnatural derivative of N-…

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

…, AV Bekish, VV Shmanai, VE Kagan, LK Mahal… - Nature chemical …, 2018 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the
glutathione-dependent lipid-peroxide-scavenging network. FINO 2 is an endoperoxide-containing …

[HTML][HTML] Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

…, TJ Yang, SD Willows, AL Mason, LK Mahal… - Nature Chemical …, 2022 - nature.com
Emerging evidence suggests that host glycans influence severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. Here, we reveal that the receptor-binding domain (…

[PDF][PDF] miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis

…, F Darvishian, J Zavadil, A Erlebacher, LK Mahal… - Cancer cell, 2011 - cell.com
To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue
and evade immune surveillance. Recent evidence suggests that microRNAs can promote …

[PDF][PDF] Development of a lectin microarray for the rapid analysis of protein glycopatterns

…, L Krishnamoorthy, D Slawek, LK Mahal - …, 2005 - ipmb.sinica.edu.tw
Glycosylation plays a role in a wide variety of biological processes including bacterial
pathogenesis, tumor cell metastasis, and inflammation.[1] Over half of all proteins are believed to …

Identification of a conserved glycan signature for microvesicles

…, KD Hendricks-Muņoz, LK Mahal - Journal of proteome …, 2011 - ACS Publications
Microvesicles (exosomes) are important mediators of intercellular communication, playing a
role in immune regulation, cancer progression, and the spread of infectious agents. The …

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

…, R Rodriguez, S Chang, L Gardner, LK Mahal… - Nature medicine, 2017 - nature.com
The progression of pancreatic oncogenesis requires immune-suppressive inflammation in
cooperation with oncogenic mutations. However, the drivers of intratumoral immune tolerance …

A useful guide to lectin binding: machine-learning directed annotation of 57 unique lectin specificities

…, W Eng, DF Smith, RD Cummings, LK Mahal - ACS chemical …, 2022 - ACS Publications
Glycans are critical to every facet of biology and medicine, from viral infections to embryogenesis.
Tools to study glycans are rapidly evolving; however, the majority of our knowledge is …

Analyzing the dynamic bacterial glycome with a lectin microarray approach

KL Hsu, KT Pilobello, LK Mahal - Nature chemical biology, 2006 - nature.com
Glycosylation of bacterial cell surfaces is emerging as a critical factor in symbiosis,
pathogenesis, cell-cell interactions and immune evasion 1 , 2 , 3 . The lack of high-throughput …

Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus

…, M Novelli, LB Lovat, WS Eng, LK Mahal… - Nature medicine, 2012 - nature.com
Barrett's esophagus is an example of a pre-invasive state, for which current endoscopic
surveillance methods to detect dysplasia are time consuming and inadequate. The prognosis of …