How viruses evolve within hosts can dictate infection outcomes; however, reconstructing
this process is challenging. We evaluate our multiplexed amplicon approach, PrimalSeq, to …

Background Chikungunya (CHIK) virus is a mosquito-transmitted alphavirus that causes in
humans an acute infection characterised by fever, polyarthralgia, head-ache, and myalgia. …

The family Arteriviridae presently includes a single genus Arterivirus. This genus includes
four species as the taxonomic homes for equine arteritis virus (EAV), lactate dehydrogenase-…

The error rate of RNA-dependent RNA polymerases (RdRp) affects the mutation frequency
in a population of viral RNAs. Using chikungunya virus (CHIKV), we describe a unique …

Next-generation sequencing was used for discovery and de novo assembly of a novel, highly
divergent DNA virus at the interface between the Parvoviridae and Circoviridae . The virus, …

The intrinsic plasticity of RNA viruses can facilitate host range changes that lead to epidemics.
However, evolutionary processes promoting cross-species transfers are poorly defined, …

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes chikungunya fever,
a severe, debilitating disease that often produces chronic arthralgia. Since 2004, CHIKV has …

The mechanisms by which RNA arboviruses, including chikungunya virus (CHIKV), evolve
and maintain the ability to infect vertebrate and invertebrate hosts are poorly understood. To …

Many examples of the emergence or re-emergence of infectious diseases involve the adaptation
of zoonotic viruses to new amplification hosts or to humans themselves. These include …

The dengue virus (DENV) complex is composed of four distinct but serologically related
flaviviruses, which together cause the present-day most important emerging viral disease. …