The established causal genes in Alzheimer's disease (AD), APP, PSEN1, and PSEN2, are
functionally characterized using biomarkers, capturing an in vivo profile reflecting the …

Background C‐reactive protein ( CRP ) is an established serum marker for the presence of
systemic inflammation in dogs. Results from previous experimental and clinical studies …

Directive 2010/63/EU of the European Parliament and the Council of 22 September 2010
states that at the end of a procedure, the most appropriate decision on the future of an animal …

Rehoming is an important fate, which should be considered for animals used for scientific
and educational purposes, and which is highlighted in the European Directive 2010/63 EU. In …

Fasting of mice is a common procedure, which can affect the outcome of the study as well
as animal welfare. In this study, we assess the effects of fasting, fasting duration and fasting …

The few established causal genes in Alzheimer’s disease (AD), mutations in APP and
PSENs, have been functionally characterized using biomarkers, capturing an in vivo profile …

Six traditional behavioural tests were done to evaluate the impact of inanimate enrichment
on group housed animals. The study was performed in three parts to prevent the animals’ …

In drug development, nonclinical safety assessment is pivotal for human risk assessment
and support of clinical development. Selecting the relevant/appropriate animal species for …

… Lars F Mikkelsen … Schlingmann F, Van de Weerd HA, Baumans V, Remie R, Van Zutphen
LFM. A balance … Ungar F, Halberg F. Circadian rhythm in in vitro response of mouse adrenal to …

Background and Aims Vibration-controlled transient elastography (VCTE), point shear wave
elastography (pSWE), 2-dimensional shear wave elastography (2DSWE), magnetic …