A critical component in the interpretation of systems-level studies is the inference of enriched
biological pathways and protein complexes contained within OMICs datasets. Successful …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
has triggered an ongoing global pandemic of the severe pneumonia-like disease …

Influenza A virus is an RNA virus that encodes up to 11 proteins and this small coding capacity
demands that the virus use the host cellular machinery for many aspects of its life cycle 1 . …

Several systems-level datasets designed to dissect host-pathogen interactions during influenza
A infection have been reported. However, apparent discordance among these data has …

Human immunodeficiency virus (HIV) has a small genome and therefore relies heavily on
the host cellular machinery to replicate. Identifying which host proteins and complexes come …

The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by
a coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in …

How transcription affects genome 3D organization is not well understood. We found that during
influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell chromatin …

A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection has been implicated as a determinant of severe coronavirus disease …

The adenovirus (Ad) fiber protein mediates Ad binding to the coxsackievirus and Ad receptor
(CAR) and is thus a major determinant of viral tropism. The fiber contains three domains: an …

Combination antiretroviral therapy (ART) is able to suppress HIV-1 replication to undetectable
levels. However, the persistence of latent viral reservoirs allows for a rebound of viral load …