Personal neoantigen vaccines have been envisioned as an effective approach to induce,
amplify and diversify antitumor T cell responses. To define the long-term effects of such a …

In spite of relentless efforts to devise new treatment strategies, primary glioblastomas invariably
recur as aggressive, therapy-resistant relapses and patients rapidly succumb to these …

Immune therapy is a promising field within oncology but has been unsuccessful in ovarian
cancer (OC). Still, there is rationale and evidence supporting immune therapy in OC. We …

Simple Summary Copy-number variations (CNVs) have important clinical implications for
several diseases and cancers. We reviewed 50 popular CNV calling tools and included 11 …

Background Scientific data and research results are being published at an unprecedented
rate. Many database curators and researchers utilize data and information from the primary …

Tumor T cell antigens are both diagnostically and therapeutically valuable molecules. A large
number of new peptides are examined as potential tumor epitopes each year, yet there is …

We previously developed TANTIGEN, a comprehensive online database cataloging more
than 1000 T cell epitopes and HLA ligands from 292 tumor antigens. In TANTIGEN 2.0, we …

CCL22 is a macrophage-derived immunosuppressive chemokine that recruits regulatory T
cells through the CCL22:CCR4 axis. CCL22 was shown to play a key role in suppressing anti-…

USER cloning is a fast and versatile method for engineering of plasmid DNA. We have
developed a user friendly Web server tool that automates the design of optimal PCR primers for …

RNase H–dependent PCR-enabled T-cell receptor sequencing (rhTCRseq) can be used to
determine paired alpha/beta T-cell receptor (TCR) clonotypes in single cells or perform …