User profiles for Lars Wienbrandt
Lars WienbrandtInstitute of Clinical Molecular Biology, Kiel University Verified email at ikmb.uni-kiel.de Cited by 3414 |
The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association …
Background Respiratory failure is a key feature of severe Covid-19 and a critical driver of
mortality, but for reasons poorly defined affects less than 10% of SARS-CoV-2 infected patients. …
mortality, but for reasons poorly defined affects less than 10% of SARS-CoV-2 infected patients. …
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
…, MS Vadla, EM Wacker, L Wienbrandt… - Human molecular …, 2022 - academic.oup.com
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our …
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our …
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression
…, E Ellinghaus, JC Kässens, L Wienbrandt… - Journal of Allergy and …, 2020 - Elsevier
Background Fifteen percent of atopic dermatitis (AD) liability-scale heritability could be attributed
to 31 susceptibility loci identified by using genome-wide association studies, with only 3 …
to 31 susceptibility loci identified by using genome-wide association studies, with only 3 …
[HTML][HTML] Vy-PER: eliminating false positive detection of virus integration events in next generation sequencing data
…, M Rühlemann, L Kraemer, S Mucha, L Wienbrandt… - Scientific Reports, 2015 - nature.com
Several pathogenic viruses such as hepatitis B and human immunodeficiency viruses may
integrate into the host genome. These virus/host integrations are detectable using paired-end …
integrate into the host genome. These virus/host integrations are detectable using paired-end …
1000× faster than PLINK: Combined FPGA and GPU accelerators for logistic regression-based detection of epistasis
Logistic regression as implemented in PLINK is a powerful and commonly used framework
for assessing gene-gene interactions. However, fitting regression models for each pair of …
for assessing gene-gene interactions. However, fitting regression models for each pair of …
BIGwas: Single-command quality control and association testing for multi-cohort and biobank-scale GWAS/PheWAS data
JC Kässens, L Wienbrandt, D Ellinghaus - GigaScience, 2021 - academic.oup.com
Background Genome-wide association studies (GWAS) and phenome-wide association
studies (PheWAS) involving 1 million GWAS samples from dozens of population-based …
studies (PheWAS) involving 1 million GWAS samples from dozens of population-based …
FPGA-based acceleration of detecting statistical epistasis in GWAS
L Wienbrandt, JC Kässens… - Procedia Computer …, 2014 - Elsevier
Genotype-by-genotype interactions (epistasis) are believed to be a significant source of
unexplained genetic variation causing complex chronic diseases but have been ignored in …
unexplained genetic variation causing complex chronic diseases but have been ignored in …
Parallelizing epistasis detection in GWAS on FPGA and GPU-accelerated computing systems
J González-Domínguez, L Wienbrandt… - … ACM transactions on …, 2015 - ieeexplore.ieee.org
High-throughput genotyping technologies (such as SNP-arrays) allow the rapid collection of
up to a few million genetic markers of an individual. Detecting epistasis (based on 2-SNP …
up to a few million genetic markers of an individual. Detecting epistasis (based on 2-SNP …
High-speed exhaustive 3-locus interaction epistasis analysis on FPGAs
JC Kässens, L Wienbrandt… - Journal of …, 2015 - Elsevier
Epistasis, the interaction between genes, has become a major topic in molecular and
quantitative genetics. It is believed that these interactions play a significant role in genetic …
quantitative genetics. It is believed that these interactions play a significant role in genetic …
The FPGA-based high-performance computer RIVYERA for applications in bioinformatics
L Wienbrandt - Conference on Computability in Europe, 2014 - Springer
Bioinformatics specifies a wide field of applications with generally long runtimes or huge
amounts of data to be processed – or even both. Typically, large computing clusters or special …
amounts of data to be processed – or even both. Typically, large computing clusters or special …