User profiles for Lasse Sommer Kristensen
 | Lasse Sommer KristensenAssociate Professor, Aarhus University Verified email at biomed.au.dk Cited by 7893 |
Epigenetics and cancer treatment
In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …
changes in gene expression not encoded by the DNA sequences, which are referred to as …
PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment
LS Kristensen, LL Hansen - Clinical chemistry, 2009 - academic.oup.com
Background: DNA methylation is a highly characterized epigenetic modification of the human
genome that is implicated in cancer. The altered DNA methylation patterns found in cancer …
genome that is implicated in cancer. The altered DNA methylation patterns found in cancer …
Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation
The expression patterns of endogenous circular RNA (circRNA) molecules during epidermal
stem cell (EpSC) differentiation have not previously been explored. Here, we show that …
stem cell (EpSC) differentiation have not previously been explored. Here, we show that …
[HTML][HTML] Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies
…, K Grønbæk, J Kjems, LS Kristensen - Laboratory …, 2018 - nature.com
Circular RNAs (circRNAs) are covalently closed endogenous molecules with tissue- and
disease-specific expression patterns, which have potential as diagnostic and prognostic …
disease-specific expression patterns, which have potential as diagnostic and prognostic …
[HTML][HTML] Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications
…, M Mohammadi, LS Kristensen - Journal of Experimental …, 2022 - Springer
Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development
during which epithelial cells acquire mesenchymal characteristics, and the underlying …
during which epithelial cells acquire mesenchymal characteristics, and the underlying …
Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon‐independent manner
…, L Sjö, J Christensen, L Sommer Kristensen… - Molecular …, 2018 - Wiley Online Library
Thalidomide and its derivatives, lenalidomide and pomalidomide (also known as IMiDs),
have significantly changed the treatment landscape of multiple myeloma, and the recent …
have significantly changed the treatment landscape of multiple myeloma, and the recent …
[HTML][HTML] Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation
Numerous genetic and epigenetic events driving tumorigenesis have been characterized.
However, knowledge is lacking on the particular events required for the metastatic spread of …
However, knowledge is lacking on the particular events required for the metastatic spread of …
[HTML][HTML] A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma
Cutaneous Squamous Cell Carcinoma (cSCC) is the most common and fastest-increasing
cancer with metastatic potential. Long non-coding RNAs (lncRNAs) and circular RNAs (…
cancer with metastatic potential. Long non-coding RNAs (lncRNAs) and circular RNAs (…
Limitations and advantages of MS-HRM and bisulfite sequencing for single locus methylation studies
…, TH Møller, BB Thestrup, LS Kristensen… - Expert review of …, 2010 - Taylor & Francis
The methylation-sensitive high-resolution melting (MS-HRM) protocol, as described by
Wojdacz and Dobrovic, enables detection of a methylated template in an unmethylated …
Wojdacz and Dobrovic, enables detection of a methylated template in an unmethylated …
[HTML][HTML] Aberrant methylation of cell-free circulating DNA in plasma predicts poor outcome in diffuse large B cell lymphoma
LS Kristensen, JW Hansen, SS Kristensen… - Clinical …, 2016 - Springer
Background The prognostic value of aberrant DNA methylation of cell-free circulating DNA
in plasma has not previously been evaluated in diffuse large B cell lymphoma (DLBCL). The …
in plasma has not previously been evaluated in diffuse large B cell lymphoma (DLBCL). The …