[HTML][HTML] Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas

L Sprankel, D Vizarraga, J Martín, S Manger… - Nature Structural & …, 2023 - nature.com
Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired human
pneumonia, needs to extract lipids from the host environment for survival and proliferation. …

[HTML][HTML] Structure and mechanism of the Nap adhesion complex from the human pathogen Mycoplasma genitalium

…, M Marcos-Silva, D Vizarraga, L Sprankel… - Nature …, 2020 - nature.com
Mycoplasma genitalium is a human pathogen adhering to host target epithelial cells and
causing urethritis, cervicitis and pelvic inflammatory disease. Essential for infectivity is a …

The immunodominant protein P116 is a passive transporter of cholesterol and other essential lipids

L Sprankel, D Vizarraga, J Martín, S Manger… - bioRxiv, 2022 - biorxiv.org
Many human pathogens need to extract lipids from their environment for survival and proliferation.
How the lipid uptake is accomplished on a molecular level is largely unknown, and no …

The GGDEF Domain of the Phosphodiesterase PdeB in Shewanella putrefaciens Mediates Recruitment by the Polar Landmark Protein HubP

FM Rossmann, T Rick, D Mrusek, L Sprankel… - Journal of …, 2019 - Am Soc Microbiol
Bacteria commonly exhibit a high degree of cellular organization and polarity which affect
many vital processes such as replication, cell division, and motility. In Shewanella and other …

[HTML][HTML] Cryo-electron tomography reveals the binding and release states of the major adhesion complex from Mycoplasma genitalium

L Sprankel, MP Scheffer, S Manger, UH Ermel… - PLoS …, 2023 - journals.plos.org
The nap particle is an immunogenic surface adhesion complex from Mycoplasma genitalium.
It is essential for motility and responsible for binding sialylated oligosaccharides on the …

P116 from Mycoplasma is a self-sufficient lipid uptake and delivery machinery

S Manger, SM Arghittu, L Sprankel, J Meier-Credo… - bioRxiv, 2023 - biorxiv.org
Lipid acquisition and transport are fundamental processes in all organisms, but many of the
key players remain unidentified. Here, we elucidate the lipid-cycling mechanism of the …

Immunodominant protein P116 from M. pneumoniae transports cholesterol and essential lipids

A Frangakis, L Sprankel, D Vizarraga, J Martín… - 2022 - researchsquare.com
Mycoplasma pneumoniae, responsible for approximately 30% of community-acquired human
pneumonia, needs to extract lipids from the host environment for survival and proliferation. …

Image denoising with less artefacts: novel non-linear filtering on fast patch reorderings

K Bodduna, J Weickert - arXiv preprint arXiv:2002.00638, 2020 - arxiv.org
… We thank Utz Ermel, Lasse Sprankel and Prof. Achilleas Frangakis from the Electron
Microscopy Group at the University of Frankfurt for providing us with data. We also thank our …

In-cell architecture of an actively transcribing-translating expressome

FJ O'Reilly, L Xue, A Graziadei, L Sinn, S Lenz… - Science, 2020 - science.org
Structural biology studies performed inside cells can capture molecular machines in action
within their native context. In this work, we developed an integrative in-cell structural …

Structure-aware image denoising, super-resolution, and enhancement methods

K Bodduna - 2021 - publikationen.sulb.uni-saarland.de
Denoising, super-resolution and structure enhancement are classical image processing
applications. The motive behind their existence is to aid our visual analysis of raw digital images…