… Lászlo Vigh… Lászlo Vigh … Lászlo Vigh …

Patients with type 2 diabetes have reduced gene expression of heat shock protein (HSP) 72,
which correlates with reduced insulin sensitivity. Heat therapy, which activates HSP72, …

The novel hydroxylamine derivative, bimoclomol, has been shown previously to act as a co-inducer
of several heat shock proteins (Hsp-s), enhancing the amount of these proteins …

Membranes provide the structural framework that divides cells from their environment and
that, in eukaryotic cells, permits compartmentation. They are not simply passive barriers that …

The fluidity of Synechocystis membranes was adjusted in vivo by temperature acclimation,
addition of fluidizer agent benzyl alcohol, or catalytic lipid hydrogenation specific to plasma …

Chaperones (stress proteins) are essential proteins to help the formation and maintenance
of the proper conformation of other proteins and to promote cell survival after a large variety …

Preservation of the chemical architecture of a cell or of an organism under changing and
perhaps stressful conditions is termed homeostasis. An integral feature of homeostasis is the …

Thermal stress in living cells produces multiple changes that ultimately affect membrane
structure and function. We report that two members of the family of small heat-shock proteins (…

Xenohormesis is a biological principle that explains how environmentally stressed plants
produce bioactive compounds that can confer stress resistance and survival benefits to …

… Accordingly, the Hsp co-inducing activity of bimoclomol appears highly susceptible to the
fatty acid composition and membrane fluidity of target cells (Vigh L., unpublished). In addition, …