General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …

Background Recent experimental observations suggest that, in addition to induce neuroapoptosis,
anesthetics can also interfere with synaptogenesis during brain development. The …

Pulsed radiofrequency, in which short bursts of radiofrequency energy are applied to nervous
tissue, has been recently described as an alternative technique devoid of nerve injury, a …

Isoforms of the neuronal cell adhesion molecule (NCAM) carrying the linear homopolymer
of alpha 2,8-linked sialic acid (polysialic acid, PSA) have emerged as particularly attractive …

Background Recent observations demonstrate that anesthetics rapidly impair synaptogenesis
during neuronal circuitry development. Whether these effects are lasting and depend on …

Experience-driven activity plays an essential role in the development of brain circuitry during
critical periods of early postnatal life, a process that depends upon a dynamic balance …

Mmigration of undifferentiated neural progenitors is critical for the development and repair
of the nervous system. However, the mechanisms and factors that regulate migration are not …

Genetic variation in SLC 12A5 which encodes KCC 2, the neuron‐specific cation‐chloride
cotransporter that is essential for hyperpolarizing GABA ergic signaling and formation of …

Background An increasing number of clinical observations suggest adverse neurologic
outcome after methylene blue (MB) infusion in the setting of parathyroid surgery. Hence, the aim …

Background Neonates and infants requiring anaesthesia are at risk of physiological instability
and complications, but triggers for peri-anaesthetic interventions and associations with …