Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous
fundamental aspects of antibody structure and diversification mechanisms and continue to …

A CTAB (hexadecyltrimethylammonium bromide) technique is described which has been
scaled to fit in microcentrifuge tubes. Reagents are added to increase separation of …

Tuberculosis remains second only to HIV/AIDS as the leading cause of mortality worldwide
due to a single infectious agent 1 . Despite chemotherapy, the global tuberculosis epidemic …

Understanding the physical characteristics of the local microenvironment in which
Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic …

Background Linezolid has antimycobacterial activity in vitro and is increasingly used for
patients with highly drug-resistant tuberculosis. Methods We enrolled 41 patients who had …

Mycobacterium tuberculosis and the closely related organism Mycobacterium bovis can survive
and replicate inside macrophages. Intracellular survival is at least in part attributed to the …

Background The exact role of neutrophils in the pathogenesis of TB is poorly understood.
Recent evidence suggests that neutrophils are not simply scavenging phagocytes in …

Finding new treatment-shortening antibiotics to improve cure rates and curb the alarming
emergence of drug resistance is the major objective of tuberculosis (TB) drug development. …

Macrophages in granulomas are both antimycobacterial effector and host cell for Mycobacterium
tuberculosis, yet basic aspects of macrophage diversity and function within the complex …

Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and
mechanisms of formation remain poorly understood. To understand the role of granulomas in …