Sleep spindles: mechanisms and functions
LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As one of …
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As one of …
Thalamic control of cortical states
We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving
mouse. We demonstrate that the desynchronized cortical state during active behavior is …
mouse. We demonstrate that the desynchronized cortical state during active behavior is …
[HTML][HTML] High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial
…, N Martínez, LA Maglio, LC Fernandez… - The Lancet …, 2022 - thelancet.com
Background Convalescent plasma has been proposed as an early treatment to interrupt the
progression of early COVID-19 to severe disease, but there is little definitive evidence. We …
progression of early COVID-19 to severe disease, but there is little definitive evidence. We …
Conditional recurrence-free survival of clinical complete responders managed by watch and wait after neoadjuvant chemoradiotherapy for rectal cancer in the …
Background Watch and wait is a novel management strategy in patients with rectal cancer
who have a clinical complete response after neoadjuvant chemoradiotherapy. Surveillance of …
who have a clinical complete response after neoadjuvant chemoradiotherapy. Surveillance of …
Coordinated infraslow neural and cardiac oscillations mark fragility and offline periods in mammalian sleep
Rodents sleep in bouts lasting minutes; humans sleep for hours. What are the universal needs
served by sleep given such variability? In sleeping mice and humans, through monitoring …
served by sleep given such variability? In sleeping mice and humans, through monitoring …
[PDF][PDF] Noradrenergic circuit control of non-REM sleep substates
…, G Katsioudi, C Devenoges, LMJ Fernandez… - Current Biology, 2021 - cell.com
To understand what makes sleep vulnerable in disease, it is useful to look at how wake-promoting
mechanisms affect healthy sleep. Wake-promoting neuronal activity is inhibited during …
mechanisms affect healthy sleep. Wake-promoting neuronal activity is inhibited during …
Combating inflammaging through a Mediterranean whole diet approach: the NU-AGE project's conceptual framework and design
…, C Nicoletti, D Jacobs, M Xipsiti, L Fernandez… - Mechanisms of ageing …, 2014 - Elsevier
The development of a chronic, low grade, inflammatory status named “inflammaging” is a
major characteristic of ageing, which plays a critical role in the pathogenesis of age-related …
major characteristic of ageing, which plays a critical role in the pathogenesis of age-related …
Impact of organ-preserving strategies on anorectal function in patients with distal rectal cancer following neoadjuvant chemoradiation
…, J Gama-Rodrigues, LM Fernandez… - Diseases of the Colon …, 2016 - journals.lww.com
BACKGROUND: Organ-preserving strategies have been considered for patients with distal
rectal cancer and complete or near-complete response to neoadjuvant chemoradiation to …
rectal cancer and complete or near-complete response to neoadjuvant chemoradiation to …
Organ preservation in cT2N0 rectal cancer after neoadjuvant chemoradiation therapy: the impact of radiation therapy dose-escalation and consolidation …
…, J Sabbaga, PB Aguilar, LM Fernandez… - Annals of …, 2019 - journals.lww.com
Objective: To demonstrate the difference in organ-preservation rates and avoidance of
definitive surgery among cT2N0 rectal cancer patients undergoing 2 different chemoradiation (…
definitive surgery among cT2N0 rectal cancer patients undergoing 2 different chemoradiation (…
Achieving a complete clinical response after neoadjuvant chemoradiation that does not require surgical resection: it may take longer than you think!
…, GP São Julião, LM Fernandez… - Diseases of the Colon …, 2019 - journals.lww.com
BACKGROUND: Patients with rectal cancer who achieve complete clinical response after
neoadjuvant chemoradiation have been managed by organ-preserving strategies and …
neoadjuvant chemoradiation have been managed by organ-preserving strategies and …