The underlying causes of obesity are poorly understood but probably involve complex
interactions between many neurotransmitter and neuropeptide systems involved in the regulation …

Using a genomics-based reverse pharmacological approach for screening orphan G-protein
coupled receptors, we have identified and cloned a novel high-affinity histamine receptor. …

Many applications of nanomedicines depend on the therapeutic gaining access to the interior
of cells. As most proteins and nanoparticles are taken up by endocytosis, determining the …

Opiate tolerance and dependence are major clinical and social problems. The anti-opiate
neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain modulation as well …

Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that degrades the fatty
acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic …

Per‐ and polyfluoroalkyl substances (PFAS) are a group of recalcitrant molecules that have
been used since the 1940s in a variety of applications. They are now linked to a host of …

Neuromedins are a family of peptides best known for their contractile activity on smooth
muscle preparations. The biological mechanism of action of neuromedin U remains unknown, …

Engineered nano–bio cellular interfaces driven by vertical nanostructured materials are set
to spur transformative progress in modulating cellular processes and interrogations. In …

The ligand-gated ion channel family includes receptors for serotonin (5-hydroxytryptamine, 5-HT),
acetylcholine, GABA, and glutamate. Drugs targeting subtypes of these receptors have …

Does the Supreme Court claim the power to enforce federal law only because it has been
granted subject matter jurisdiction over a case in which federal law is at stake? Or does a …