User profiles for Laura Ibanez
 | Laura Ibáñez LladoAssistant Professor, Washington University in Saint Louis Verified email at wustl.edu Cited by 3934 |
A common haplotype lowers PU. 1 expression in myeloid cells and delays onset of Alzheimer's disease
A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849
controls identified eight previously reported AD risk loci and 14 novel loci associated with age at …
controls identified eight previously reported AD risk loci and 14 novel loci associated with age at …
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders
Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and
without Alzheimer disease (AD; n control = 13; n AD = 83) from the Knight Alzheimer Disease …
without Alzheimer disease (AD; n control = 13; n AD = 83) from the Knight Alzheimer Disease …
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF)
has been associated with Alzheimer’s disease (AD). TREM2 plays a critical role in …
has been associated with Alzheimer’s disease (AD). TREM2 plays a critical role in …
[HTML][HTML] A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Background Alzheimer’s disease (AD) is the most common form of dementia. This
neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the …
neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the …
Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms
Objective To determine whether the extent of overlap of the genetic architecture among the
sporadic late-onset Alzheimer's Disease (sLOAD), familial late-onset AD (fLOAD), sporadic …
sporadic late-onset Alzheimer's Disease (sLOAD), familial late-onset AD (fLOAD), sporadic …
Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke
Stroke penumbra injury caused by excess glutamate is an important factor in determining
stroke outcome; however, several therapeutic approaches aiming to rescue the penumbra …
stroke outcome; however, several therapeutic approaches aiming to rescue the penumbra …
PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis
Rationale: Ischemic stroke is among the leading causes of adult disability. Part of the variability
in functional outcome after stroke has been attributed to genetic factors but no locus has …
in functional outcome after stroke has been attributed to genetic factors but no locus has …
Early neurological change after ischemic stroke is associated with 90-day outcome
L Heitsch, L Ibanez, C Carrera, MM Binkley, D Strbian… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Large-scale observational studies of acute ischemic stroke (AIS)
promise to reveal mechanisms underlying cerebral ischemia. However, meaningful …
promise to reveal mechanisms underlying cerebral ischemia. However, meaningful …
[HTML][HTML] TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
…, FHG Farias, MV Fernández, L Ibanez… - Molecular …, 2019 - Springer
Background Low frequency coding variants in TREM2 are associated with Alzheimer disease
(AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD …
(AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between AD …