The liver provides a tolerogenic immune niche exploited by several highly prevalent pathogens
as well as by primary and metastatic tumors. We have sampled healthy and hepatitis B …

Antiviral T cell responses in hepatotropic viral infections such as hepatitis B virus (HBV) are
profoundly diminished and prone to apoptotic deletion. In this study, we investigate whether …

Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: the virus
can either replicate without pathological consequences or trigger immune-mediated …

B cells are increasingly recognized as playing an important role in the ongoing control of
hepatitis B virus (HBV). The development of antibodies against the viral surface antigen (HBV …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Natural killer cells (NK) are highly enriched in the human liver, where they can regulate
immunity and immunopathology. We probed them for a liver-resident subset, distinct from …

T cells undergo profound metabolic changes to meet the increased energy demands of
maintaining an antiviral response. We postulated that differences in metabolic reprogramming …

Disclosures: LJ Pallett reported personal fees from Gilead Sciences outside the submitted
work. OE Amin reported grants from Gilead Sciences outside the submitted work. X. Forns …

Optimal immune activation of naïve CD8 T cells requires signal 1 mediated by the T cell
receptor, signal 2 mediated by co-stimulation and signal 3 provided by pro-inflammatory …

Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC),
yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both …