There are no therapies that reverse the proteotoxic misfolding events that underpin fatal
neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Parkinson's …

Bacterial ClpB and yeast Hsp104 are homologous Hsp100 protein disaggregases that serve
critical functions in proteostasis by solubilizing protein aggregates. Two AAA+ nucleotide …

Introduction: Clinical and preclinical studies suggest that regulation of nicotinic acetylcholine
receptors (nAChR) maybe involved in the etiology of withdrawal symptoms. Methods: We …

10.7554/eLife.05397.001 Semen is the main vector for HIV transmission and contains
amyloid fibrils that enhance viral infection. Available microbicides that target viral components …

Clinical and preclinical studies suggest that nicotinic acetylcholine receptors are involved in
affective disorders; therefore, the potential therapeutic value of nicotinic partial agonists as …

Despite its discovery over 30 years ago, human immunodeficiency virus (HIV) continues to
threaten public health worldwide. Semen is the principal vehicle for the transmission of this …

The AAA+ protein disaggregase, Hsp104, increases fitness under stress by reversing stress-induced
protein aggregation. Natural Hsp104 variants might exist with enhanced, selective …

Hsp104 is an AAA+ protein disaggregase with powerful amyloid-remodeling activity. All
nonmetazoan eukaryotes express Hsp104 while eubacteria express an Hsp104 ortholog, ClpB. …

Naturally occurring proteolytic fragments of prostatic acid phosphatase (PAP248-286 and
PAP85-120) and semenogelins (SEM1 and SEM2) form amyloid fibrils in seminal fluid, which …

Heat shock protein (Hsp) 104 is a hexameric ATPases associated with diverse cellular activities
motor protein that enables cells to survive extreme stress. Hsp104 couples the energy of …