User profiles for Laura M. Huckins
 | Laura M. Huckins, PhDAssociate Professor, Dept of Psychiatry, Yale Verified email at yale.edu Cited by 12179 |
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
…, B Herpertz-Dahlmann, W Herzog, LM Huckins… - Nature …, 2019 - nature.com
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …
[HTML][HTML] Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics
, … 107 Siminoff Laura A. 106 Traino Heather M … - Nature …, 2018 - nature.com
Scalable, integrative methods to understand mechanisms that link genetic variants with
phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a …
phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a …
Genetic analyses of diverse populations improves discovery for complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …
biology of complex traits, drug development and clinical guidelines. However, the majority …
A genome-wide association study of anorexia nervosa
…, JAB Floyd, LM Thornton, LM Huckins… - Molecular …, 2014 - nature.com
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …
Leveraging base-pair mammalian constraint to understand genetic variation and human disease
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …
attempts to elucidate biological mechanisms are impeded by an inability to discern which …
Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four health care systems
Objective: Individuals at high risk for schizophrenia may benefit from early intervention, but
few validated risk predictors are available. Genetic profiling is one approach to risk …
few validated risk predictors are available. Genetic profiling is one approach to risk …
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Transcriptomic imputation approaches combine eQTL reference panels with large-scale
genotype data in order to test associations between disease and gene expression. These genic …
genotype data in order to test associations between disease and gene expression. These genic …
Clinical characteristics of hospitalized Covid-19 patients in New York City
Background The coronavirus 2019 (Covid-19) pandemic is a global public health crisis, with
over 1.6 million cases and 95,000 deaths worldwide. Data are needed regarding the clinical …
over 1.6 million cases and 95,000 deaths worldwide. Data are needed regarding the clinical …
Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice
Opioid use disorder (OUD) looms as one of the most severe medical crises facing society.
More effective therapeutics will require a deeper understanding of molecular changes …
More effective therapeutics will require a deeper understanding of molecular changes …