Leptin plays an important role in the control of food intake, energy expenditure, metabolism,
and body weight. This hormone also has a key function in the regulation of glucose …

Type 2 diabetes is a chronic, heterogeneous syndrome characterized by insulin resistance
and pancreatic β-cell dysfunction or death. Among several environmental factors contributing …

Glucose homeostasis is precisely regulated by glucagon and insulin, which are released by
pancreatic α- and β-cells, respectively. While β-cells have been the focus of intense research…

The recent discovery that genetically modified α cells can regenerate and convert into β-like
cells in vivo holds great promise for diabetes research. However, to eventually translate …

Background Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy
but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains …

Aims/hypothesis Three hallmarks of the pancreatic islets in early human type 1 diabetes are
overexpression of HLA class I, endoplasmic reticulum (ER) stress and beta cell apoptosis. …

Pancreatic β-cells are destroyed by an autoimmune attack in type 1 diabetes. Linkage and
genome-wide association studies point to >50 loci that are associated with the disease in the …

Disturbances of circadian rhythms have been associated with obesity and type 2 diabetes.
The nuclear receptor Rev-erbα was suggested to link circadian rhythms and metabolism in …

Pancreatic α cells are exposed to metabolic stress during the evolution of type 2 diabetes (T2D),
but it remains unclear whether this affects their survival. We used electron microscopy to …

Type 1 diabetes (T1D) is an autoimmune disease leading to β-cell destruction. MicroRNAs (miRNAs)
are small noncoding RNAs that control gene expression and organ formation. They …