[HTML][HTML] Recent updates on the involvement of PI3K/AKT/mTOR molecular cascade in the pathogenesis of hyperproliferative skin disorders
L Mercurio, C Albanesi, S Madonna - Frontiers in Medicine, 2021 - frontiersin.org
PhosphoInositide-3 Kinase (PI3K) represents a family of different classes of kinases which
control multiple biological processes in mammalian cells, such as cell growth, proliferation …
control multiple biological processes in mammalian cells, such as cell growth, proliferation …
[HTML][HTML] IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment
L Mercurio, M Morelli, C Scarponi… - Cell death & …, 2018 - nature.com
IL-36 cytokines, a subgroup of IL-1 family, comprise IL-36α, IL-36β, and IL-36γ agonists,
abundantly expressed in psoriatic skin, and IL-36RA and IL-38 antagonists. In psoriatic skin, IL-…
abundantly expressed in psoriatic skin, and IL-36RA and IL-38 antagonists. In psoriatic skin, IL-…
[HTML][HTML] Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model
L Mercurio, MA Ajmone-Cat, S Cecchetti… - Journal of experimental …, 2016 - Springer
Background The CXCL12/CXCR4 pathway regulates tumor cell proliferation, metastasis,
angiogenesis and the tumor-microenvironment cross-talk in several solid tumors, including …
angiogenesis and the tumor-microenvironment cross-talk in several solid tumors, including …
[HTML][HTML] Interleukin (IL)-17/IL-36 axis participates to the crosstalk between endothelial cells and keratinocytes during inflammatory skin responses
L Mercurio, CM Failla, L Capriotti, C Scarponi… - PLoS …, 2020 - journals.plos.org
In inflammatory skin conditions, such as psoriasis, vascular enlargement is associated with
endothelial cell proliferation, release of cytokines and adhesion molecule expression. …
endothelial cell proliferation, release of cytokines and adhesion molecule expression. …
Children with ADHD engage in less physical activity
LY Mercurio, S Amanullah, N Gill… - Journal of attention …, 2021 - journals.sagepub.com
Background: Children with ADHD should engage in physical activity, given its known role as
a treatment adjunct. Objective: The main objective of this study is to assess the relationship …
a treatment adjunct. Objective: The main objective of this study is to assess the relationship …
Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects
…, M Fujita, T Yamauchi, L Mercurio… - European Journal of …, 2021 - Wiley Online Library
The IL‐1 family member IL‐38 (IL1F10) suppresses inflammatory and autoimmune conditions.
Here, we report that plasma concentrations of IL‐38 in 288 healthy Europeans correlate …
Here, we report that plasma concentrations of IL‐38 in 288 healthy Europeans correlate …
[HTML][HTML] Selective immunomodulation of inflammatory pathways in keratinocytes by the janus kinase (JAK) inhibitor tofacitinib: implications for the employment of JAK …
M Morelli, C Scarponi, L Mercurio… - Journal of immunology …, 2018 - hindawi.com
IFN-γ and IL-22 are deeply involved in the pathogenesis of psoriasis, as they boost the
expression of inflammatory genes and alter proliferative and differentiative programs in …
expression of inflammatory genes and alter proliferative and differentiative programs in …
Prospective validation of a rapid host gene expression test to discriminate bacterial from viral respiratory infection
…, H Wang, I Ugalde, S Amanullah, L Mercurio… - JAMA network …, 2022 - jamanetwork.com
Importance Bacterial and viral causes of acute respiratory illness (ARI) are difficult to clinically
distinguish, resulting in the inappropriate use of antibacterial therapy. The use of a host …
distinguish, resulting in the inappropriate use of antibacterial therapy. The use of a host …
Paradoxical psoriasis induced by TNF‐α blockade shows immunological features typical of the early phase of psoriasis development
…, M Morelli, C Scarponi, L Mercurio… - The Journal of …, 2020 - Wiley Online Library
Immunomodulation with anti‐TNF‐α is highly effective in the treatment of various immune‐mediated
inflammatory diseases, including hidradenitis suppurativa (HS). However, this may …
inflammatory diseases, including hidradenitis suppurativa (HS). However, this may …
[HTML][HTML] Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21
L Mercurio, D Lulli, F Mascia, E Dellambra… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Psoriasis is a chronic Th1/Th17 lymphocytes-mediated inflammatory skin disease, in which
epidermal keratinocytes exhibit a peculiar senescent state, resistance to apoptosis and the …
epidermal keratinocytes exhibit a peculiar senescent state, resistance to apoptosis and the …