Rationale: Respiratory syncytial virus (RSV) is the most frequent cause of significant lower
respiratory illness in infants and young children, but its pathogenesis is not fully understood. …

Nrf2 is a key transcription factor that regulates cellular redox and defense responses. However,
permanent Nrf2 activation in human lung carcinomas promotes pulmonary malignancy …

Aims: Nrf2 is an essential transcription factor for protection against oxidant disorders.
However, its role in organ development and neonatal disease has received little attention. …

Background Peroxisome proliferator-activated receptors (PPARs) are a family of three (PPARα,
-β/δ, and -γ) nuclear receptors. In particular, PPARα is involved in regulation of fatty acid …

Nrf2 is essential to antioxidant response element (ARE)-mediated host defense. Sulforaphane
(SFN) is a phytochemical antioxidant known to affect multiple cellular targets including …

Cytochrome P450 epoxygenase metabolites of arachidonic acid, EETs, have multiple
cardiovascular effects, including reduction of blood pressure, protection against myocardial …

BACKGROUND: Control of the inflammatory response is critical to maintaining homeostasis,
and failure to do so contributes to the burden of chronic inflammation associated with …

Background Respiratory syncytial virus (RSV) is the global leading cause of lower
respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease …

Purpose: Although the ABCB1 (P-glycoprotein) drug transporter is a constituent of several
blood–tissue barriers (ie, blood–brain and blood–nerve), its participation in a putative blood–…

NRF2 protects against oxidant-associated airway disorders via cytoprotective gene
induction. To examine if NRF2 is an important determinant of respiratory syncytial virus (RSV) …