Fragile X syndrome (FXS), the most common genetic form of mental retardation and autism,
is caused by loss-of-function mutations in an RNA-binding protein, Fragile X Mental …

Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating
behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine …

Adolescent nicotine exposure is associated with long-term use, and it has been suggested
that this vulnerability to addiction may relate to lasting anxiogenic effects of the drug. However…

Analyses of data from genome-wide association studies on unrelated individuals have shown
that, for human traits and diseases, approximately one-third to two-thirds of heritability is …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become
the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies …

… Therefore I would like to dedicate this book to my mother and father, Nancy and Ron Smith,
who ensured not just that I got the education that took me away but that it was a political …

Genes and mechanisms involved in common complex diseases, such as the autoimmune
disorders that affect approximately 5% of the population, remain obscure. Here we identify …

Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease
progression that suggest diverse host immune responses. We performed an integrated immune …

INTRODUCTION Clinical outcomes of human severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection range from silent infection to lethal coronavirus disease 2019 (…