User profiles for Laura O’Regan
 | Laura O'ReganPostdoctoral Research Associate, University of Bristol Verified email at bristol.ac.uk Cited by 1655 |
Cell cycle regulation by the NEK family of protein kinases
Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus nidulans
led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is required …
led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is required …
[HTML][HTML] Mitotic regulation by NIMA-related kinases
The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell
cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans, as …
cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans, as …
The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis
Nek6 and Nek7 are members of the NIMA-related serine/threonine kinase family. Previous
work showed that they contribute to mitotic progression downstream of another NIMA-related …
work showed that they contribute to mitotic progression downstream of another NIMA-related …
Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells
Histone deacetylases 1 and 2 (HDAC1/2) form the core catalytic components of corepressor
complexes that modulate gene expression. In most cell types, deletion of both Hdac1 and …
complexes that modulate gene expression. In most cell types, deletion of both Hdac1 and …
Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain
…, S Busacca, L O'Regan… - Proceedings of the …, 2014 - National Acad Sciences
Proteins of the echinoderm microtubule-associated protein (EMAP)-like (EML) family contribute
to formation of the mitotic spindle and interphase microtubule network. They contain a …
to formation of the mitotic spindle and interphase microtubule network. They contain a …
[PDF][PDF] An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9
MW Richards, L O'Regan, C Mas-Droux, JMY Blot… - Molecular cell, 2009 - cell.com
Mitosis is controlled by multiple protein kinases, many of which are abnormally expressed in
human cancers. Nek2, Nek6, Nek7, and Nek9 are NIMA-related kinases essential for proper …
human cancers. Nek2, Nek6, Nek7, and Nek9 are NIMA-related kinases essential for proper …
Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain
MW Richards, L O'Regan, D Roth… - Biochemical …, 2015 - wrap.warwick.ac.uk
… Laura O’Regan carried out immunofluorescence microscopy and analysed the resulting
data, while immunoprecipitation experiments were performed and analysed by Laura O'Regan …
data, while immunoprecipitation experiments were performed and analysed by Laura O'Regan …
[HTML][HTML] Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
…, SG Burgess, P Gallego, S Yeoh, L O'Regan… - Nature …, 2015 - nature.com
Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7 and
Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated by …
Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated by …
Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression
R Adib, JM Montgomery, J Atherton, L O'Regan… - Science …, 2019 - science.org
EML4 is a microtubule-associated protein that promotes microtubule stability. We investigated
its regulation across the cell cycle and found that EML4 was distributed as punctate foci …
its regulation across the cell cycle and found that EML4 was distributed as punctate foci …
[HTML][HTML] Alternative treatment options to ALK inhibitor monotherapy for EML4-ALK-driven lung cancer
S Papageorgiou, SL Pashley, L O'Regan, S Khan… - Cancers, 2022 - mdpi.com
Simple Summary Lung cancer remains one of the most common and difficult cancers to treat.
However, excellent progress in identifying the genetic causes of lung cancers has revealed …
However, excellent progress in identifying the genetic causes of lung cancers has revealed …