All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization …

During the development of the cerebral cortex, progenitor cells produce neurons that migrate
to laminar positions appropriate for their birth dates, adopt specific neuronal identities, and …

In September of 2011, the National Institute of Neurological Disorders and Stroke (NINDS),
the Eunice Kennedy Shriver National Institute of Child Health and Human Development (…

Both genetic and epigenetic factors play important roles in the rate and severity of classic
autism and autism spectrum disorders (ASDs). This review focuses on DNA methylation as a …

In drug discovery and development, traditional assessment of human patients and preclinical
subjects occurs at limited time points in potentially stressful surroundings (ie, the clinic or a …

There are numerous hallmarks of aging in mammals, but no unifying cause has been identified.
In budding yeast, aging is associated with a loss of epigenetic information that occurs in …

Rett syndrome (RTT) is an autism-spectrum disorder caused by mutations in the X-linked
gene encoding methyl-CpG-binding protein 2 (MeCP2). Abnormalities in social behavior, …

Retinal ganglion cells (RGCs) relay information about the outside world to multiple subcortical
targets within the brain. This information is either used to dictate reflexive behaviors or …

Folate and choline, two nutrients involved in the one-carbon metabolic cycle, are intimately
involved in regulating DNA integrity, synthesis, biogenic amine synthesis, and methylation. In …

Despite a broad spectrum of anti-arthritic drugs currently on the market, there is a constant
demand to develop improved therapeutic agents. Efficient compound screening and rapid …