Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging

LA Harsan, J Steibel, A Zaremba, A Agin… - Journal of …, 2008 - Soc Neuroscience
The failure of the remyelination processes in multiple sclerosis contributes to the formation
of chronic demyelinated plaques that lead to severe neurological deficits. Long-term …

[HTML][HTML] Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis

…, WT Chang, M Dhenain, D von Elverfeldt, LA Harsan… - Neuroimage, 2020 - Elsevier
Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer
the possibility to non-invasively probe whole-brain network dynamics and to investigate the …

Chronic murine toxoplasmosis is defined by subtle changes in neuronal connectivity

A Parlog, LA Harsan, M Zagrebelsky… - Disease models & …, 2014 - journals.biologists.com
Recent studies correlate chronic Toxoplasma gondii (T. gondii) infection with behavioral
changes in rodents; additionally, seropositivity in humans is reported to be associated with …

Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome

…, BL Kieffer, LA Harsan - Proceedings of the …, 2016 - National Acad Sciences
Connectome genetics seeks to uncover how genetic factors shape brain functional connectivity;
however, the causal impact of a single gene’s activity on whole-brain networks remains …

Fine-grained mapping of mouse brain functional connectivity with resting-state fMRI

…, HL Lee, J Hennig, D von Elverfeldt, LA Harsan - Neuroimage, 2014 - Elsevier
Understanding the intrinsic circuit-level functional organization of the brain has benefited
tremendously from the advent of resting-state fMRI (rsfMRI). In humans, resting-state functional …

The connectomics of brain demyelination: functional and structural patterns in the cuprizone mouse model

…, T Bienert, J Hennig, D von Elverfeldt, LA Harsan - Neuroimage, 2017 - Elsevier
Connectomics of brain disorders seeks to reveal how altered brain function emerges from
the architecture of cerebral networks; however the causal impact of targeted cellular damage …

Mu opioid receptors in gamma-aminobutyric acidergic forebrain neurons moderate motivation for heroin and palatable food

…, A Matifas, K Befort, C Gavériaux-Ruff, LA Harsan… - Biological …, 2017 - Elsevier
… e , Audrey Matifas a , Katia Befort a j k , Claire Gavériaux-Ruff a , Laura-Adela Harsan b c
h , Dominik von Elverfeldt h , Jurgen Hennig h , Alain Gratton d … Brigitte L. Kieffer a d …

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

…, M Karatas, AE Mechling, LA Harsan… - Disease models & …, 2018 - journals.biologists.com
Growing evidence supports the implication of DYRK1A in the development of cognitive deficits
seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that …

Mapping remodeling of thalamocortical projections in the living reeler mouse brain by diffusion tractography

LA Harsan, C Dávid, M Reisert… - Proceedings of the …, 2013 - National Acad Sciences
A major challenge in neuroscience is to accurately decipher in vivo the entire brain circuitry (connectome)
at a microscopic level. Currently, the only methodology providing a global …

In vivo visualization of gold-loaded cells in mice using x-ray computed tomography

…, RD Kirch, BHJ Juurlink, C Hall, LA Harsan… - … , Biology and Medicine, 2013 - Elsevier
The ability to perform cell tracking using x-ray computed tomography combined with gold
nanoparticles has been demonstrated recently on ex vivo samples using different malignant …