The age at onset of motor symptoms in Huntington’s disease (HD) is driven by HTT CAG
repeat length but modified by other genes. In this study, we used exome sequencing of 683 …

It is well established that some members of the Deg/ENaC super family of amiloride sensitive
ion channels can participate directly in the transduction of mechanical stimuli by sensory …

The naked mole-rat (NMR) is a subterranean rodent that has gained significant attention from
the biomedical research community in recent years as molecular mechanisms underlying …

Acid-sensing ion channels (ASICs) are a family of ion channels comprised of six subunits
encoded by four genes and they are expressed throughout the peripheral and central nervous …

The troglomorphic phenotype shared by diverse cave-dwelling animals is regarded as a
classical example of convergent evolution. One unresolved question is whether the …

Objectives The only proteins known to be modified by O-linked lipidation are Wnts and
ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. …

To spatially co-exist and differentially specify fates within developing tissues, morphogenetic
cues must be correctly positioned and interpreted. Here, we investigate mouse hair follicle …

Proper localization of receptors for synaptic organizing factors is crucial for synapse formation.
Wnt proteins promote synapse assembly through Frizzled (Fz) receptors. In hippocampal …

Acid-sensing ion channels (ASICs) form both homotrimeric and heterotrimeric ion channels
that are activated by extracellular protons and are involved in a wide range of physiological …

The acid-sensing ion channels (ASICs) are a family of ion channels expressed throughout
the mammalian nervous system. The principal activator of ASICs is extracellular protons, and …