Males and females responses to gestational overnutrition set the stage for subsequent sex-specific
differences in adult onset non communicable diseases. Placenta, as a widely …

DNA methylation is an essential epigenetic mark in mammals that has to be re-established
after each round of DNA replication. The protein UHRF1 is essential for this process; it has …

MBD5 and MBD6 are two members of the methyl‐CpG‐binding domain (MBD) family of
proteins that are poorly characterized. Studies performed thus far have failed to show binding of …

Landmark discoveries made nearly two decades ago identified known transcriptional regulators
as histone lysine methyltransferases. Since then, the field of lysine methylation signaling …

Alterations of DNA methylation landscapes and machinery are a hallmark of many human
diseases. A prominent case is the ICF syndrome, a rare autosomal recessive immunological/…

Epigenetic mechanisms are essential to establish and safeguard cellular identities in mammals.
They dynamically regulate the expression of genes, transposable elements and higher-…

The protein UHRF1 is crucial for DNA methylation maintenance. The tandem Tudor domain (TTD)
of UHRF1 binds histone H3K9me2/3 with micromolar affinity, as well as unmethylated …

DNA ligase I (LigI), the predominant enzyme that joins Okazaki fragments, interacts with
PCNA and Pol δ. LigI also interacts with UHRF1, linking Okazaki fragment joining with DNA …

Background Methylation of cytosines in DNA (5mC methylation) is a major epigenetic
modification that modulates gene expression and constitutes the basis for mechanisms regulating …

Long interspersed element 1 (L1) retrotransposons are implicated in human disease and
evolution. Their global activity is repressed by DNA methylation, but deciphering the regulation …