Engineering and study of protein function by directed evolution has been limited by the
technical requirement to use global mutagenesis or introduce DNA libraries. Here, we develop …

Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …

It is estimated that 350 million individuals worldwide suffer from rare diseases, which are
predominantly caused by mutation in a single gene 1 . The current molecular diagnostic rate is …

Gene co-expression networks capture biologically important patterns in gene expression
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …

RNA sequencing (RNA-seq) has emerged as a powerful approach to discover disease-causing
gene regulatory defects in individuals affected by genetically undiagnosed rare disorders…

In aging, skeletal muscle strength and regenerative capacity decline, due in part to functional
impairment of muscle stem cells (MuSCs), yet the underlying mechanisms remain elusive. …

Little is known about epigenetic mechanisms in birds with the exception of the phenomenon
of dosage compensation of sex chromosomes, although such mechanisms could be …

Induced pluripotent stem cells (iPSCs) are an established cellular system to study the impact
of genetic variants in derived cell types and developmental contexts. However, in their …

ATP synthase, H + transporting, mitochondrial F1 complex, δ subunit (ATP5F1D; formerly
ATP5D) is a subunit of mitochondrial ATP synthase and plays an important role in coupling …

Genomic imprinting is an epigenetic mechanism by which alleles of some specific genes are
expressed in a parent-of-origin manner. It has been observed in mammals and marsupials, …