The role of histone modifications in transcription remains incompletely understood. Here,
we examine the relationship between histone modifications and transcription using …

Our genomes encode a wealth of transcription initiation regions (TIRs) that can be identified
by their distinctive patterns of actively elongating RNA polymerase. We previously …

How evolutionary changes at enhancers affect the transcription of target genes remains an
important open question. Previous comparative studies of gene expression have largely …

How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II) during
transcription remains poorly understood. Here, we used naturally occurring genetic variation …

The advent of animal husbandry and hunting increased human exposure to zoonotic
pathogens. To understand how a zoonotic disease may have influenced human evolution, we …

Background Despite clinically demonstrated accuracy in next generation sequencing (NGS)
data, many clinical laboratories continue to confirm variants with Sanger sequencing, which …

Background Canine visceral hemangiosarcoma (HSA) is a highly aggressive cancer of
endothelial origin that closely resembles visceral angiosarcoma in humans, both clinically and …

Rgtsvm provides a fast and flexible support vector machine (SVM) implementation for the R
language. The distinguishing feature of Rgtsvm is that support vector classification and …

Genome sequencing (GS) is a powerful clinical tool used for the comprehensive diagnosis of
germline disorders. GS library preparation typically involves mechanical DNA fragmentation…

Background β2-microglobulin amyloidosis was first described in the 1980s as a protein
deposition disease associated with long-term haemodialysis. More recently, two inherited forms …