The causes of amyotrophic lateral sclerosis (ALS), a devastating human neurodegenerative
disease, are poorly understood, although the protein TDP-43 has been suggested to have a …

Objective To see whether the distribution patterns of phosphorylated 43kDa TAR DNA‐binding
protein (pTDP‐43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit …

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …

Background TDP-43 is a major component of the ubiquitinated inclusions that characterise
amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with …

To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find
associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced …

… M Van Deerlin, Ning Yan, Ahmed Yousef, Howard I Hurtig, Andrew Siderowf, Murray Grossman,
Corey T McMillan, Bruce Miller, John E Duda, David J Irwin, David Wolk, Lauren Elman, …

Amyotrophic lateral sclerosis (ALS) is a devastating and universally fatal neurodegenerative
disease. Mutations in two related RNA-binding proteins, TDP-43 and FUS, that harbor prion-…

TAR DNA-binding protein (TDP-43) has been recently described as a major pathological
protein in both frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U) and …

Background Pathological 43-kDa transactivating responsive sequence DNA-binding protein
(TDP-43) has been identified recently as the major disease protein in amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor
neurons. Mutations in related RNA-binding proteins TDP-43, FUS/TLS and TAF15 have been …