Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation
disorder, caused by mutations in the cohesin-loading protein NIPBL 1 , 2 for nearly 60% of …

The discovery that half of the mammalian protein-coding genome is regulated by the circadian
clock has clear implications for medicine. Recent studies demonstrated that the circadian …

Genome biology approaches have made enormous contributions to our understanding of
biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and …

Circadian rhythms modulate many aspects of physiology. Knowledge of the molecular basis
of these rhythms has exploded in the last 20 years. However, most of these data are from …

The intricate connection between the circadian clock and metabolism remains poorly
understood. We used high temporal resolution metabolite profiling to explore clock regulation of …

Cornelia de Lange syndrome (CdLS) is a multisystem genetic disorder with distinct facies,
growth failure, intellectual disability, distal limb anomalies, gastrointestinal and neurological …

The aryl hydrocarbon receptor (AHR) is the ligand-activated transcription factor responsible
for mediating the toxicological effects of dioxin and xenobiotic metabolism. However, recent …

Skin is the largest organ in the body and serves important barrier, regulatory, and sensory
functions. The epidermal layer shows rhythmic physiological responses to daily environmental …

Hearing loss is the most prevalent sensory perception deficit in humans, affecting 1/500
newborns, can be syndromic or nonsyndromic and is genetically heterogeneous. Nearly 80% of …

Total anomalous pulmonary venous connection (TAPVC) is a potentially lethal congenital
disorder that occurs when the pulmonary veins do not connect normally to the left atrium, …