Long-range regulatory interactions play an important role in shaping gene-expression
programs. However, the genomic features that organize these activities are still poorly …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal differentiation
when expressed in neural progenitor cells. The mechanisms by which proneural genes …

Mutations in somatic cells generate a heterogeneous genomic population and may result in
serious medical conditions. Although cancer is typically associated with somatic variations, …

The majority of neural stem cells (NSCs) in the adult brain are quiescent, and this fraction
increases with aging. Although signaling pathways that promote NSC quiescence have been …

The proneural transcription factor Ascl1 coordinates gene expression in both proliferating
and differentiating progenitors along the neuronal lineage. Here, we used a cellular model of …

The increasing number of complete and nearly complete metazoan genome sequences
provides a significant amount of material for large-scale comparative genomic analysis. Finding …

We present here a Sleeping Beauty–based transposition system that offers a simple and
efficient way to investigate the regulatory architecture of mammalian chromosomes in vivo. With …

Background The initiating nucleotide found at the 5’ end of primary transcripts has a distinctive
triphosphorylated end that distinguishes these transcripts from all other RNA species. …

Most organisms possess circadian clocks that are able to anticipate the day/night cycle and
are reset or “entrained” by the ambient light. In the zebrafish, many organs and even cultured …

The predominant methodology for DNA methylation analysis relies on the chemical deamination
by sodium bisulfite of unmodified cytosine to uracil to permit the differential readout of …