From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
JN Feige, L Gelman, L Michalik, B Desvergne… - Progress in lipid …, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …
Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein …
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor implicated in
adipocyte differentiation and insulin sensitivity. We investigated whether PPARγ expression is …
adipocyte differentiation and insulin sensitivity. We investigated whether PPARγ expression is …
[HTML][HTML] Cohesin and CTCF control the dynamics of chromosome folding
…, J Zuin, M Kryzhanovska, S Smallwood, L Gelman… - Nature …, 2022 - nature.com
In mammals, interactions between sequences within topologically associating domains
enable control of gene expression across large genomic distances. Yet it is unknown how …
enable control of gene expression across large genomic distances. Yet it is unknown how …
[HTML][HTML] From mechanotransduction to extracellular matrix gene expression in fibroblasts
M Chiquet, L Gelman, R Lutz, S Maier - Biochimica et Biophysica Acta (BBA …, 2009 - Elsevier
Tissue mechanics provide an important context for tissue growth, maintenance and function.
On the level of organs, external mechanical forces largely influence the control of tissue …
On the level of organs, external mechanical forces largely influence the control of tissue …
[HTML][HTML] The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor γ modulator that promotes adipogenesis
JN Feige, L Gelman, D Rossi, V Zoete… - Journal of Biological …, 2007 - ASBMB
The ability of pollutants to affect human health is a major concern, justified by the wide
demonstration that reproductive functions are altered by endocrine disrupting chemicals. The …
demonstration that reproductive functions are altered by endocrine disrupting chemicals. The …
[PDF][PDF] A unique PPARγ ligand with potent insulin-sensitizing yet weak adipogenic activity
S Rocchi, F Picard, J Vamecq, L Gelman, N Potier… - Molecular cell, 2001 - cell.com
FMOC-L-Leucine (FL-Leu) is a chemically distinct PPARγ ligand. Two molecules of FL-Leu
bind to the ligand binding domain of a single PPARγ molecule, making its mode of receptor …
bind to the ligand binding domain of a single PPARγ molecule, making its mode of receptor …
PixFRET, an ImageJ plug‐in for FRET calculation that can accommodate variations in spectral bleed‐throughs
…, W Wahli, B Desvergne, L Gelman - Microscopy research …, 2005 - Wiley Online Library
Fluorescence resonance energy transfer (FRET) allows the user to investigate interactions
between fluorescent partners. One crucial issue when calculating sensitized emission FRET …
between fluorescent partners. One crucial issue when calculating sensitized emission FRET …
[HTML][HTML] p300 interacts with the N-and C-terminal part of PPARγ2 in a ligand-independent and-dependent manner, respectively
L Gelman, G Zhou, L Fajas, E Raspé… - Journal of Biological …, 1999 - ASBMB
The nuclear peroxisome proliferator-activated receptor γ (PPARγ) activates the transcription
of multiple genes involved in intra- and extracellular lipid metabolism. Several cofactors are …
of multiple genes involved in intra- and extracellular lipid metabolism. Several cofactors are …
In vivo activation of PPAR target genes by RXR homodimers
The ability of a retinoid X receptor (RXR) to heterodimerize with many nuclear receptors,
including LXR, PPAR, NGF1B and RAR, underscores its pivotal role within the nuclear receptor …
including LXR, PPAR, NGF1B and RAR, underscores its pivotal role within the nuclear receptor …
The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARα-dependent mechanisms
…, C Winkler, E Bedu, M Bueno, L Gelman… - Environmental …, 2010 - ehp.niehs.nih.gov
Background The modulation of energetic homeostasis by pollutants has recently emerged as
a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is …
a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is …