Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor implicated in
adipocyte differentiation and insulin sensitivity. We investigated whether PPARγ expression is …

In mammals, interactions between sequences within topologically associating domains
enable control of gene expression across large genomic distances. Yet it is unknown how …

Tissue mechanics provide an important context for tissue growth, maintenance and function.
On the level of organs, external mechanical forces largely influence the control of tissue …

The ability of pollutants to affect human health is a major concern, justified by the wide
demonstration that reproductive functions are altered by endocrine disrupting chemicals. The …

FMOC-L-Leucine (FL-Leu) is a chemically distinct PPARγ ligand. Two molecules of FL-Leu
bind to the ligand binding domain of a single PPARγ molecule, making its mode of receptor …

Fluorescence resonance energy transfer (FRET) allows the user to investigate interactions
between fluorescent partners. One crucial issue when calculating sensitized emission FRET …

The nuclear peroxisome proliferator-activated receptor γ (PPARγ) activates the transcription
of multiple genes involved in intra- and extracellular lipid metabolism. Several cofactors are …

The ability of a retinoid X receptor (RXR) to heterodimerize with many nuclear receptors,
including LXR, PPAR, NGF1B and RAR, underscores its pivotal role within the nuclear receptor …

Background The modulation of energetic homeostasis by pollutants has recently emerged as
a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is …