Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be enriched
in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in vivo, we …

Small noncoding microRNAs (miRNA) regulate the expression of target mRNAs by repressing
their translation or orchestrating their sequence-specific degradation. In this study, we …

Systemic inflammatory reactions have been postulated to exacerbate neurodegenerative
diseases via microglial activation. We now demonstrate in vivo that repeated systemic …

MicroRNAs (miRNAs) are ubiquitously expressed small non-coding RNAs that, in most cases,
negatively regulate gene expression at the post-transcriptional level. miRNAs are involved …

Epithelial to mesenchymal transition (EMT) is a key step toward metastasis. MCF7 breast
cancer cells conditionally expressing the EMT master regulator SNAI1 were used to identify …

While the autophagic process is mainly regulated at the post-translational level, a growing
body of evidence suggests that autophagy might also be regulated at the transcriptional level. …

Major efforts have been put in anti-angiogenic treatment for glioblastoma (GBM), an aggressive
and highly vascularized brain tumor with dismal prognosis. However clinical outcome …

Actin-related proteins (ARPs) are key players in cytoskeleton activities and nuclear functions.
Two complexes, ARP2/3 and ARP1/11, also known as dynactin, are implicated in actin …

Glioblastoma (GBM) is known to be a heterogeneous disease; however, the genetic composition
of the cells within a given tumour is only poorly explored. In the advent of personalised …

Background: Hypoxia is negatively associated with glioblastoma (GBM) patient survival and
contributes to tumour resistance. Anti-angiogenic therapy in GBM further increases hypoxia …