Episodes de mortalité massive de moules bleues observés en 2014 dans les Pertuis charentais

…, P Haffner, C Dubreuil, N Faury, L Baillon… - Bulletin …, 2015 - hal.science
Des épisodes de mortalité massive (90-100 %) ont été observés au sein des élevages de
moules touchant à la fois les animaux adultes et les juvéniles au printemps 2014, dans les …

[HTML][HTML] The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

TP Peacock, DH Goldhill, J Zhou, L Baillon… - Nature …, 2021 - nature.com
SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and
the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (…

[HTML][HTML] Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study

…, A Abdolrasouli, OC Swann, L Baillon… - The Lancet …, 2020 - thelancet.com
Background Severe COVID-19 has a high mortality rate. Comprehensive pathological
descriptions of COVID-19 are scarce and limited in scope. We aimed to describe the …

[HTML][HTML] Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

…, EM Jones, MMH Tan, RC Saputil, L Baillon… - Nature …, 2022 - nature.com
Although alterations in myeloid cells have been observed in COVID-19, the specific underlying
mechanisms are not completely understood. Here, we examine the function of classical …

Increased transmission of SARS-CoV-2 lineage B. 1.1. 7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape

…, TP Peacock, R Frise, N Goonawardane, L Baillon… - BioRxiv, 2021 - biorxiv.org
Lineage B.1.1.7 (Variant of Concern 202012/01) is a new SARS-CoV-2 variant which was
first sequenced in the UK in September 2020 before becoming the majority strain in the UK …

The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells

TP Peacock, DH Goldhill, J Zhou, L Baillon, R Frise… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 enters cells via its spike glycoprotein which must be cleaved sequentially at the
S1/S2, then the S2’ cleavage sites (CS) to mediate membrane fusion. SARS-CoV-2 has a …

[PDF][PDF] Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway

…, WT Harvey, R Kugathasan, R Frise, L Baillon… - Cell Reports, 2022 - cell.com
SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs, and
farmed mink. Since the start of the 2019 pandemic, several reverse zoonotic outbreaks of SARS…

[HTML][HTML] Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1

H Stölting, L Baillon, R Frise, K Bonner, RJ Hewitt… - Mucosal …, 2022 - Elsevier
Children are less likely than adults to suffer severe symptoms when infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while influenza A H1N1 severity is …

[HTML][HTML] Ostreid herpesvirus type 1 replication and host response in adult Pacific oysters, Crassostrea gigas

A Segarra, L Baillon, D Tourbiez, A Benabdelmouna… - Veterinary …, 2014 - Springer
Since 2008, massive mortality outbreaks associated with OsHV-1 detection have been reported
in Crassostrea gigas spat and juveniles in several countries. Nevertheless, adult oysters …

[HTML][HTML] An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization

…, R Penn, OK Platt, K Sukhova, L Baillon… - Nature …, 2023 - nature.com
Human ANP32A and ANP32B are essential but redundant host factors for influenza virus
genome replication. While most influenza viruses cannot replicate in edited human cells …