[HTML][HTML] The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis
Background Molecular diagnostics are considered the most promising route to achievement
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex (MTBC…
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex (MTBC…
Assessment of epidemiological and genetic characteristics and clinical outcomes of resistance to bedaquiline in patients treated for rifampicin-resistant tuberculosis: a …
…, H Ferreira, J Hughes, L Joseph… - The Lancet Infectious …, 2022 - thelancet.com
Background Bedaquiline improves outcomes of patients with rifampicin-resistant and
multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We …
multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We …
[HTML][HTML] Defining bedaquiline susceptibility, resistance, cross-resistance and associated genetic determinants: a retrospective cohort study
Background Bedaquiline (BDQ) is a novel agent approved for use in combination treatment
of multi-drug resistant tuberculosis (MDR-TB). We sought to determine BDQ epidemiological …
of multi-drug resistant tuberculosis (MDR-TB). We sought to determine BDQ epidemiological …
[HTML][HTML] Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis
…, SJ Hoosdally, NA Ismail, L Jarrett, L Joseph… - The Lancet …, 2023 - thelancet.com
Background Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis;
however, the understanding of resistance mechanisms is poor, which is hampering rapid …
however, the understanding of resistance mechanisms is poor, which is hampering rapid …
Validation of bedaquiline phenotypic drug susceptibility testing methods and breakpoints: a multilaboratory, multicountry study
…, C Desmaretz, R Hasan, L Joseph… - Journal of Clinical …, 2020 - Am Soc Microbiol
Drug-resistant tuberculosis persists as a major public health concern. Alongside efficacious
treatments, validated and standardized drug susceptibility testing (DST) is required to …
treatments, validated and standardized drug susceptibility testing (DST) is required to …
The integrity and yield of genomic DNA isolated from whole blood following long-term storage at− 30 C
…, B Ndlovu, A Sobalisa, ST Duze, L Joseph… - Biopreservation and …, 2018 - liebertpub.com
Long-term storage of whole blood can affect the integrity of DNA if it is not done under optimal
conditions. The aim of this study was to determine whether long-term storage (2–19 years) …
conditions. The aim of this study was to determine whether long-term storage (2–19 years) …
Genotype–Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis
TS Brown, L Tang, SV Omar, L Joseph… - Clinical Infectious …, 2024 - academic.oup.com
Background Emerging resistance to bedaquiline (BDQ) threatens to undermine advances in
the treatment of drug-resistant tuberculosis (DRTB). Characterizing serial Mycobacterium …
the treatment of drug-resistant tuberculosis (DRTB). Characterizing serial Mycobacterium …
[HTML][HTML] Epidemiological cut-offs for Sensititre susceptibility testing of Mycobacterium tuberculosis: interpretive criteria cross validated with whole genome sequencing
NA Ismail, F Ismail, L Joseph, N Govender, L Blows… - Scientific reports, 2020 - nature.com
Universal drug susceptibility testing (DST) is an important requirement of the End TB Strategy.
The Sensititre broth micro-dilution assay (BMD) tests multiple drugs quantitatively. We …
The Sensititre broth micro-dilution assay (BMD) tests multiple drugs quantitatively. We …
A data compendium of Mycobacterium tuberculosis antibiotic resistance
The Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC)
presents here a compendium of 15,211 Mycobacterium tuberculosis global clinical …
presents here a compendium of 15,211 Mycobacterium tuberculosis global clinical …
Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis
South Africa remains challenged with a high tuberculosis burden accompanied by an
increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation …
increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation …