User profiles for Lawrence Steinman
 | lawrence steinmanstanford university Verified email at stanford.edu Cited by 78167 |
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin
…, C Cannon, LC Fritz, F Sanchez-Madrid, L Steinman… - Nature, 1992 - nature.com
EXPERIMENTAL autoimmune encephalomyelitis (EAE) is an inflammatory condition of the
central nervous system with similarities to multiple sclerosis 1,2 . In both diseases, circulating …
central nervous system with similarities to multiple sclerosis 1,2 . In both diseases, circulating …
A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage
L Steinman - Nature medicine, 2007 - nature.com
For over 35 years, immunologists have divided T-helper (T H ) cells into functional subsets. T-helper
type 1 (T H 1) cells—long thought to mediate tissue damage—might be involved in …
type 1 (T H 1) cells—long thought to mediate tissue damage—might be involved in …
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters
…, ET Pelkey, L Steinman… - Proceedings of the …, 2000 - National Acad Sciences
Certain proteins contain subunits that enable their active translocation across the plasma
membrane into cells. In the specific case of HIV-1, this subunit is the basic domain Tat 49–57 (…
membrane into cells. In the specific case of HIV-1, this subunit is the basic domain Tat 49–57 (…
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
…, JR Oksenberg, CS Raine, R Heller, L Steinman - Nature medicine, 2002 - nature.com
Microarray analysis of multiple sclerosis (MS) lesions obtained at autopsy revealed increased
transcripts of genes encoding inflammatory cytokines, particularly interleukin-6 and -17, …
transcripts of genes encoding inflammatory cytokines, particularly interleukin-6 and -17, …
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
…, EM Hur, M Bravo, DJ Mitchell, RA Sobel, L Steinman… - Nature, 2002 - nature.com
Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, which are
approved for cholesterol reduction, may also be beneficial in the treatment of inflammatory …
approved for cholesterol reduction, may also be beneficial in the treatment of inflammatory …
The T lymphocyte in experimental allergic encephalomyelitis
SS Zamvil, L Steinman - Annual review of immunology, 1990 - annualreviews.org
Discrimination between foreign and self antigens is necessary for normal immune function.
Whereas exposure to foreign antigens can lead to their elimination and subsequent specific …
Whereas exposure to foreign antigens can lead to their elimination and subsequent specific …
[HTML][HTML] Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system
L Steinman - Cell, 1996 - cell.com
Multiple sclerosis (MS) is the most common autoimmune disease involving the nervous
system. In the United States∼ 250,000 individuals suffer from MS. The first clinical signs of MS …
system. In the United States∼ 250,000 individuals suffer from MS. The first clinical signs of MS …
[HTML][HTML] Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain
…, S Zhang, RC Axtell, S Ju, J Mu, L Zhang, L Steinman… - Molecular Therapy, 2011 - cell.com
In this study, exosomes used to encapsulate curcumin (Exo-cur) or a signal transducer and
activator of transcription 3 (Stat3) inhibitor, ie, JSI124 (Exo-JSI124) were delivered …
activator of transcription 3 (Stat3) inhibitor, ie, JSI124 (Exo-JSI124) were delivered …
Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).
…, W Ridgway, C Dinisco, L Steinman… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
Experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis,
is an autoimmune disorder seen in mice and rats following immunization with myelin basic …
is an autoimmune disorder seen in mice and rats following immunization with myelin basic …