Tissue barriers that restrict passage of liquids, ions, and larger solutes are essential for the
development of multicellular organisms. In simple organisms this allows distinct cell types to …

A critical function of the intestinal mucosa is to form a barrier that separates luminal contents
from the interstitium. This intestinal barrier is compromised in a number of intestinal diseases…

Increasing evidence suggests that the tight junction is a dynamically regulated structure.
Cytoskeletal reorganization, particularly myosin light chain phosphorylation‐‐induced …

Epithelial tight junctions form a barrier against passive paracellular flux. This barrier is
regulated by complex physiologic and pathophysiologic signals that acutely fine-tune tight …

Binding of either ligand or agonistic antibodies to the death receptor CD95 (APO-1/Fas) induces
the formation of the death-inducing signaling complex (DISC). We now show that signal …

BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a multifactorial disease
thought to be caused by alterations in epithelial function, innate and adaptive immunity, and …

A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key factor for
hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is also required …

Epithelial paracellular barrier function, determined primarily by tight junction permeability, is
frequently disrupted in disease. In the intestine, barrier loss can be mediated by tumor …

The tight junction defines epithelial organization. Structurally, the tight junction is comprised
of transmembrane and membrane-associated proteins that are thought to assemble into …

It is generally reasoned that lethal infections caused by opportunistic pathogens develop
permissively by invading a host that is both physiologically stressed and immunologically …