Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary
metabolites with many medicinal properties, including the essential anti-cancer therapeutics …

Surveillance of the extracellular environment by immune receptors is of central importance to
eukaryotic survival. The rice receptor kinase XA21, which confers robust resistance to most …

Flowers of the hop plant provide both bitterness and “hoppy” flavor to beer. Hops are, however,
both a water and energy intensive crop and vary considerably in essential oil content, …

Targeted proteomics is a convenient method determining enzyme expression levels, but a
quantitative analysis of these proteomic data has not been fully explored yet. Here, we …

Lipid composition determines the physical properties of biological membranes and can vary
substantially between and within organisms. We describe a specific role for the viscosity of …

Branched five carbon (C 5) alcohols are attractive targets for microbial production due to
their desirable fuel properties and importance as platform chemicals. In this study, we …

The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …

Isopentenyl pyrophosphate (IPP) toxicity presents a challenge in engineered microbial
systems since its formation is unavoidable in terpene biosynthesis. In this work, we develop an …

Realizing the promise of metabolic engineering has been slowed by challenges related to
moving beyond proof-of-concept examples to robust and economically viable systems. Key to …

Monoterpenes (C 10 isoprenoids) are the main components of essential oils and are possible
precursors for many commodity chemicals and high energy density fuels. Monoterpenes …