Major international projects are underway that are aimed at creating a comprehensive catalogue
of all the genes responsible for the initiation and progression of cancer 1 , 2 , 3 , 4 , 5 , 6 …

Translating whole-exome sequencing (WES) for prospective clinical use may have an impact
on the care of patients with cancer; however, multiple innovations are necessary for clinical …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding
epithelial organoids that retain their tissue identity. We report the establishment of tumor …

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we
report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, …

PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma
(ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated…

Cervical cancer is responsible for 10–15% of cancer-related deaths in women worldwide 1 ,
2 . The aetiological role of infection with high-risk human papilloma viruses (HPVs) in …

As researchers begin probing deep coverage sequencing data for increasingly rare
mutations and subclonal events, the fidelity of next generation sequencing (NGS) laboratory …

Oncotator is a tool for annotating genomic point mutations and short nucleotide insertions/deletions
(indels) with variant‐ and gene‐centric information relevant to cancer researchers. …

Mutect2 is a somatic variant caller that uses local assembly and realignment to detect SNVs
and indels. Assembly implies whole haplotypes and read pairs, rather than single bases, as …