Antiestrogens include agents such as tamoxifen, toremifene, raloxifene, and fulvestrant.
Currently, tamoxifen is the only drug approved for use in breast cancer chemoprevention, and it …

It has been suggested that environmental contaminants that mimic the effects of estrogen
contribute to disruption of the reproductive systems of animals in the wild, and to the high …

Background: High intake of soy foods has been proposed to contribute to the low breast
cancer risk in Asian countries. However, results of epidemiologic studies of this association are …

We hypothesized that feeding pregnant rats with a high-fat diet would increase both
circulating 17β-estradiol (E2) levels in the dams and the risk of developing carcinogen-induced …

Diet is estimated to contribute to approximately 50% of all newly diagnosed breast cancers.
As such, a search for dietary factors differentially consumed among populations with …

OBJECTIVE: To establish normal, trimester-specific reference intervals for serum 17β-estradiol,
progesterone (P), 17α-hydroxyprogesterone, cortisol, 11-deoxycortisol, androstenedione…

While more than 70% of breast cancers express estrogen receptor-α (ER+), endocrine therapies
targeting these receptors often fail. The molecular mechanisms that underlie treatment …

Tamoxifen has been prescribed to millions of females for breast cancer prevention or treatment.
However, tamoxifen is known to significantly enhance the risk of developing endometrial …

Breast cancer is the most commonly diagnosed cancer among women worldwide. Many
women have become more aware of the benefits of increasing fruit consumption, as part of a …

Genistein in soy activates estrogen receptor (ER)-α and ERβ and acts as an estradiol in
multiple target tissues. Because estrogens increase breast cancer risk and genistein promotes …